The study showed that psilocybin alleviated the pain of chronic migraines, which is often treated with drugs like opiates. It also reduced the severity of symptoms and improved sleep quality.

Psilocybe cubensis is a species of mushroom that has been used for centuries in the treatment of migraines. A single dose of psilocybin may provide lasting effects to those who suffer from cluster headaches.

Note: Veriheal does not condone the unlawful use of medicinal drugs such as psilocybin magic mushrooms, but recognizes that it occurs due to the present illegal status, which we want to alter by pushing for study, legal access, and responsible usage. Always seek medical advice before trying alternative treatments.

Those of you who have had a migraine know that it is much more than just discomfort. Cannabis has been found to have characteristics that may help with the symptoms of this debilitating disease, but a new research suggests that a single dosage of psilocybin might offer long-term therapeutic advantages. Migraine medications are notoriously ineffective, therefore the presence of cannabis and psilocybin as potentially helpful therapies is crucial for people seeking relief. So, let’s take a look at the research that discovered psilocybin’s potential for long-term therapeutic effects. 

Although Psilocybin is illegal, research is ongoing.

Psilocybin is the psychoactive chemical present in some mushrooms, which is why they’re also known as “magic” mushrooms, “shrooms,” or even “liberty caps.” The drug has long been utilized in rituals and spiritual activities as an entheogen. Psilocybin is still banned in many parts of the globe, but there is a growing body of support and research being done to enhance the prospects of legalization.

If you’re interested in learning more about psilocybin and how it may be used with cannabis for medicinal purposes, read this article. 

Psilocybin as a Migraine Treatment

A group of academics released a study in Neurotherapeutics that looked at the “migraine-suppressing effects of psilocybin.” While psilocybin users may testify to the substance’s therapeutic benefits, research has yet to back up many of the claims.

This is the first research to utilize a double-blind, placebo-controlled design to evaluate psilocybin’s effectiveness for migraines. A double-blind study is one in which neither the participants nor the researchers know whether each participant is receiving the placebo or the real drug. The placebo-controlled portion of the trial implies that the researchers are testing whether psilocybin has an impact by comparing it to a drug that has no effect. 

“As a headache medicine specialist, I see the need for a better knowledge of headache diseases, particularly migraine, and the need for additional therapeutic options,” research author Emmanuelle Schindler said. I’ve also spent a lot of time studying the neuropharmacology of psychedelics and appreciate its potential to assist us learn more about how the human brain works.” 

After learning that “patients with certain headache disorders reported lasting improvements after just a single or few doses of psilocybin or other psychedelics,” Schindler wondered if “these drugs couldn’t help us better understand the underlying pathology in headache disorders, as well as serve as a new form of treatment.”


Seven migraine sufferers, both women and men, took part in the research. At initially, the subjects were given a placebo, albeit no one knew it at the time. They subsequently progressed to taking modest dosages of psilocybin, both in pill form. The subjects also kept a migraine diary, which they started two weeks after receiving the first pill and two weeks after receiving the active dosage of psilocybin. 

Psilocybin was shown to help reduce migraine pain and severity in a study.

The researchers discovered that psilocybin was linked to a decrease in pain intensity as well as an improvement in the functional deficits that are prevalent in migraine sufferers. “This research is extremely early and does not serve as a guidance for how to treat migraine with psilocybin,” Schindler told PsyPost, “but it does provide some valuable information.” 

When speaking with PsyPost, Schindler emphasized that the study was not focused on a particular migraine episode, but rather the disease as a whole. She also said that the psilocybin dosages were low and that the subjects had no psychedelic experiences. 

Despite the fact that the individuals only took psilocybin once throughout the trial, it continued to give comfort “equivalent to the impact of taking a daily preventative medicine,” according to the researchers. “There is no other oral medication that can accomplish this,” Schindler said, citing the tiny dosage with long-lasting benefits, the decrease in discomfort, and the increase in functioning.

This new research was connected to another of Schindler’s investigations released in 2015, which showed that psilocybin was similarly helpful against a painful condition called cluster headache. Lower dosages were not only utilized and successful in this research, but they were also chosen by patients who indicated a distaste for taking larger amounts, according to Schindler. 

More evidence-based research is required.

While modest dosages of psilocybin have been shown to be beneficial and have long-lasting therapeutic benefits, much remains unknown. This covers things like various dosages and their safety when taken on a regular basis, as well as any possible differences between magical mushroom strains, if there are any. 

Self-medicating with psychedelics may be hazardous, which is why we suggest using psilocybin only as part of a professional’s treatment plan. If you are in a place where psilocybin is legal, try microdosing. This is when you take little dosages more often (i.e daily). It’s also essential to note that, despite a slew of encouraging anecdotal accounts, the verdict on many key elements of utilizing psilocybin as a therapy is still out. 

If you’ve used psilocybin to treat migraines, headaches, or pains, please tell us about your experience in the comments area below. 


Chane Leigh, nicknamed The Bud Fairy, is a cannabis advocate and enthusiast from South Africa with a fiery personality and a desire to travel. She enjoys educating others and challenging social conventions.

The lions mane mushroom for migraines is a fungus that has been found to provide lasting effects for migraines.

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